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Effect of Curcumin on Gut Microbiota in IBS

December 20, 2019


This study aims to investigate how the food supplement curcumin affects children with irritable bowel syndrome (IBS) in terms of changes in microbiota and symptom relief. Curcumin is a spice commonly used in Asian cooking and it will be administered in a capsule in this study to see if it can be used as a treatment for FGID (functional gastrointestinal disorders.)


Study Information

Participants will be placed into two groups: one will receive the treatment arm of 50 mg capsule of curcumin twice a day or three times a day (depending on the participant’s weight) for 8 weeks in a capsule. The second group will receive a placebo capsule of a similar size, shape, and color for 8 weeks. Investigators are looking for 50 participants. The study started on August 1, 2018 and is estimated to be completed by March 2020.


Inclusion Criteria


  • Ages 10-18 years
  • Fulfill the Rome IV criteria for diarrhea predominant IBS
  • English speaking
  • Able to swallow curcumin/placebo capsules


Exclusion Criteria


  • Weigh less than 35 kg
  • On any form of dietary restrictions
  • Taken probiotics one month before enrollment
  • Antibiotic treatment one month before enrollment
  • Any of the following: IBD, Celiac disease, Peptic ulcer disease, H. Pylori gastritis, Abnormality of gastrointestinal tract, Previous abnormal endoscope, Previous abdominal surgeries, Gallstones, Biliary tract obstructions, Liver pathologies, Liver failure, Active GI infection, Positive stool cultures, Drug or alcohol abuse
  • Concomitant immunological/hematological/neoplastic/heart/ renal/pulmonary condition
  • Any other medical condition or taking any form of drug(s) which can explain the current symptoms
  • Take oral or intravenous drugs which could have potential drug interaction with curcumin
  • Lactating or pregnant or planning to become pregnant
  • Developmental delay
  • Parents that are developmentally delayed
  • Have a diet high in curcumin/turmeric



Medical College of Wisconsin

Milwaukee, Wisconsin, United States, 53226

Contact: Manu Sood, MD    414-266-3690



Medical College of Wisconsin

Clinical & Translational Science Institute of Southeast Wisconsin

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