Because IBS is a group of symptoms, it is very important to make sure that a thorough history and physical examination is performed. This ensures that patients don’t have any alarming symptoms or any other signs of other conditions such as inflammatory bowel disease, celiac disease, microscopic colitis, or a thyroid disease. All of those conditions can mimic the symptoms of IBS, so it’s important for your physician to ask all the necessary questions to exclude these other conditions. Sometimes it’s not clear, and the doctor may require blood work or stool tests to rule out infections. They may even require an endoscopy or a colonoscopy if the symptoms are not clear-cut and you have risk factors for some of these other conditions.