Initially, IBS was a symptom-based treatment, meaning that if you would get medications to treat the symptoms of abdominal pain, diarrhea, or constipation. In recent years, developments have led to new treatment options. One in particular is Rifaximin, which is a very specific type of antibiotic that is not absorbed in the digestive tract and seems to help patients with irritable bowel syndrome or SIBO. Other treatments for IBS include SSRIs (Selective Serotonin Reuptake Inhibitors) which are also called antidepressants. These medications seem to work on the nerves of the digestive tract and help reduce the pain, cramping, and bloating.